| Applications: | WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | PD-L2 Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: | WB: 1:500 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | PDCD1LG2 |
| Gene ID: | 80380 |
| Uniprot ID: | PD1L2_HUMAN |
| Tissue Specificity | Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus. |
| Function | Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production. |
| Peptide Name | Programmed Cell Death 1 Ligand 2 Pd-1 Ligand 2 Pd-L2 Pdcd1 Ligand 2 Programmed Death Ligand 2 Butyrophilin B7-Dc B7-Dc Cd Antigen Cd273 |
| Database Links | Reactome: R-HSA-389948 |
| Cellular Localisation | Isoform 3: Secreted Isoform 2: Endomembrane System Single-Pass Type I Membrane Protein Isoform 1: Cell Membrane |
| Alternative Peptide Names | Programmed Cell Death 1 Ligand 2 protein Pd-1 Ligand 2 protein Pd-L2 protein Pdcd1 Ligand 2 protein Programmed Death Ligand 2 protein Butyrophilin B7-Dc protein B7-Dc protein Cd Antigen Cd273 protein PDCD1LG2 protein B7DC protein CD273 protein PDCD1L2 protein PDL2 protein |
Information sourced from Uniprot.org