• Mouse YKL-40/CHI3L1 protein (Recombinant) (C-His) (STJP001506)

Mouse YKL-40/CHI3L1 protein (Recombinant) (C-His) (STJP001506)

SKU:
STJP001506

£97.50 - £291.50
Current Stock:
Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: <0.1 EU/Mu g
Gene Symbol: Chi3l1
Gene ID: 12654
Uniprot ID: CH3L1_MOUSE
Immunogen: Recombinant Mouse YKL-40/CHI3L1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Tyr30-Ala389) of mouse YKL-40/CHI3L1 (Accession #NP_031721.2) fused with a 6×His tag at the C-terminus.
Immunogen Sequence: YKLVCYFTSWSQYREGVGSF LPDAIQPFLCTHIIYSFANI SSDNMLSTWEWNDESNYDKL NKLKTRNTNLKTLLSVGGWK FGEKRFSEIASNTERRTAFV RSVAPFLRSYGFDGLDLAWL YPRLRDKQYFSTLIKELNAE FTKEVQPGREKLLLSAALSA GKVAIDTGYDIAQIAQHLDF INLMTYDFHGVWRQITGHHS PLFQGQKDTRFDRYSNVNYA VQYMIRLGAQASKLLMGIP
Function Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.
Protein Name Chitinase-3-Like Protein 1
Brp39 Protein
Breast Regression Protein 39
Cartilage Glycoprotein 39
Cgp-39
Gp-39
Database Links Reactome: R-MMU-6798695
Cellular Localisation Secreted
Extracellular Space
Cytoplasm
Endoplasmic Reticulum
Detected In Bronchoalveolar Lavage (Bal) Fluids
Localizes Mainly To Endoplasmic Reticulum When Overexpressed In Cells
With Some Protein Also Detected Throughout The Cytoplasm
Alternative Protein Names Chitinase-3-Like Protein 1 protein
Brp39 Protein protein
Breast Regression Protein 39 protein
Cartilage Glycoprotein 39 protein
Cgp-39 protein
Gp-39 protein
Chi3l1 protein
Brp39 protein
Chil1 protein

Information sourced from Uniprot.org

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