Mouse MELK (Maternal Embryonic Leucine Zipper Kinase) Sandwich ELISA Kit Ready-To-Use Kit (STJE0016941)

Mouse MELK (Maternal Embryonic Leucine Zipper Kinase) Sandwich ELISA Kit Ready-To-Use Kit (STJE0016941)

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STJE0016941
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Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.057ng/mL
Detection Limit: 0.156-10ng/mL
Short Description : This MELK Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse tissue homogenates, cell lysates or other biological fluids..
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Melk
Gene ID: 17279
Uniprot ID: MELK_MOUSE
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Expressed in testis, ovary, thymus, spleen and T-cell. Expressed by neural progenitors: highly enriched in cultures containing multipotent progenitors.
Post Translational Modifications Autophosphorylated: autophosphorylation of the T-loop at Thr-167 and Ser-171 is required for activation.
Function Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity.phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.
Protein Name Maternal Embryonic Leucine Zipper Kinase
Protein Kinase Pk38
Mpk38
Tyrosine-Protein Kinase Melk
Database Links
Cellular Localisation Cell Membrane
Peripheral Membrane Protein
Alternative ELISA Names Maternal Embryonic Leucine Zipper Kinase ELISA kit
Protein Kinase Pk38 ELISA kit
Mpk38 ELISA kit
Tyrosine-Protein Kinase Melk ELISA kit
Melk ELISA kit
Kiaa0175 ELISA kit
Pk38 ELISA kit
output

Information sourced from Uniprot.org

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