| Tissue Specificity | The highest level is seen throughout the brain, but it is also found in the stomach, heart, testis, adipose tissue, muscle, spleen, liver, and kidney. |
| Post Translational Modifications | Phosphorylation at Ser-1159 and Ser-1179 by CDK5 in response to DNA damage in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Huntingtin: Cleaved by caspases downstream of the polyglutamine stretch. Huntingtin, myristoylated N-terminal fragment: Myristoylated at Gly-530, following proteolytic cleavage at Asp-529. |
| Function | Huntingtin: May play a role in microtubule-mediated transport or vesicle function. Huntingtin, myristoylated N-terminal fragment: Promotes the formation of autophagic vesicles. |
| Protein Name | HuntingtinHuntington Disease Protein HomologHd Protein Homolog Cleaved Into - Huntingtin - Myristoylated N-Terminal Fragment |
| Database Links | |
| Cellular Localisation | Huntingtin: CytoplasmNucleusShuttles Between Cytoplasm And Nucleus In A Ran Gtpase-Independent MannerHuntingtinMyristoylated N-Terminal Fragment: Cytoplasmic VesicleAutophagosome |
| Alternative ELISA Names | Huntingtin ELISA kitHuntington Disease Protein Homolog ELISA kitHd Protein Homolog Cleaved Into - Huntingtin - Myristoylated N-Terminal Fragment ELISA kitHtt ELISA kitHd ELISA kitHdh ELISA kit |
| output | |
Information sourced from Uniprot.org
