| Function | Intracellular carrier for long-chain fatty acids and related active lipids, such as endocannabinoids, that regulate the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors. Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta.which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation. May be involved in keratinocyte differentiation. |
| Protein Name | Fatty Acid-Binding Protein 5Epidermal-Type Fatty Acid-Binding ProteinE-FabpFatty Acid-Binding Protein - EpidermalKeratinocyte Lipid-Binding ProteinPsoriasis-Associated Fatty Acid-Binding Protein HomologPa-Fabp |
| Database Links | Reactome: R-MMU-163560Reactome: -MMU-5362517Reactome: -MMU-6798695 |
| Cellular Localisation | CytoplasmNucleusSynapsePostsynaptic DensitySecretedLocalizes Primarily To The CytoplasmUpon Certain Ligand BindingA Conformation Change Exposes A Nuclear Localization Motif And The Protein Is Transported Into NucleusSecreted By AstrocytesBut Not By Neurons |
| Alternative Protein Names | Fatty Acid-Binding Protein 5 proteinEpidermal-Type Fatty Acid-Binding Protein proteinE-Fabp proteinFatty Acid-Binding Protein - Epidermal proteinKeratinocyte Lipid-Binding Protein proteinPsoriasis-Associated Fatty Acid-Binding Protein Homolog proteinPa-Fabp proteinFabp5 proteinFabpe proteinKlbp proteinMal1 protein |
Information sourced from Uniprot.org
