| Post Translational Modifications | N-glycosylated. Phosphorylated on tyrosine residues in response to beta-glucan binding. |
| Function | Lectin that functions as a pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Induces phosphorylation of SCIMP after binding beta-glucans. |
| Protein Name | C-Type Lectin Domain Family 7 Member ABeta-Glucan ReceptorC-Type Lectin Superfamily Member 12Dendritic Cell-Associated C-Type Lectin 1Dc-Associated C-Type Lectin 1Dectin-1Cd Antigen Cd369 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinEnriched On Zymosan PhagosomesEnrichment Does Not Depend On Opsonization |
| Alternative Protein Names | C-Type Lectin Domain Family 7 Member A proteinBeta-Glucan Receptor proteinC-Type Lectin Superfamily Member 12 proteinDendritic Cell-Associated C-Type Lectin 1 proteinDc-Associated C-Type Lectin 1 proteinDectin-1 proteinCd Antigen Cd369 proteinClec7a proteinBgr proteinClecsf12 proteinDectin1 protein |
Information sourced from Uniprot.org
