| Tissue Specificity | Detected in the heart, spleen, lung, peritoneal exudate cells and leukocytes. |
| Post Translational Modifications | |
| Function | Chemokine receptor that plays a crucial role in regulating immune cell migration, inflammation, and immune responses. Contributes to the inflammatory response by recruiting immune cells, such as monocytes, macrophages, T-cells, and dendritic cells, to sites of inflammation for the clearance of pathogens and the resolution of tissue damage. When activated by its ligands including CCL3, CCL5-9, CCL13-16 and CCL23, triggers a signaling cascade within immune cells, leading to their migration towards the source of the chemokine. For example, mediates neutrophil migration after activation by CCL3 leading to the sequential release of TNF-alpha and leukotriene B4. Mediates also monocyte migration upon CXCL4 binding. Activation by CCL5 results in neuroinflammation through the ERK1/2 signaling pathway. |
| Protein Name | C-C Chemokine Receptor Type 1C-C Ckr-1Cc-Ckr-1Ccr-1Ccr1Macrophage Inflammatory Protein 1-Alpha ReceptorMip-1alpha-RRantes-RCd Antigen Cd191 |
| Database Links | Reactome: R-MMU-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative ELISA Names | C-C Chemokine Receptor Type 1 ELISA kitC-C Ckr-1 ELISA kitCc-Ckr-1 ELISA kitCcr-1 ELISA kitCcr1 ELISA kitMacrophage Inflammatory Protein 1-Alpha Receptor ELISA kitMip-1alpha-R ELISA kitRantes-R ELISA kitCd Antigen Cd191 ELISA kitCcr1 ELISA kitCmkbr1 ELISA kit |
| output | |
Information sourced from Uniprot.org
