Mouse CACNa1S (Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit) Sandwich ELISA Kit Ready-To-Use Kit (STJE0014015)

Mouse CACNa1S (Calcium Channel, Voltage Dependent, L-Type, Alpha 1S Subunit) Sandwich ELISA Kit Ready-To-Use Kit (STJE0014015)

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STJE0014015
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Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.101ng/mL
Detection Limit: 0.312-20ng/mL
Short Description : This CACNa1S Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse tissue homogenates or other biological fluids..
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Cacna1s
Gene ID: 12292
Uniprot ID: CAC1S_MOUSE
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity
Post Translational Modifications The alpha-1S subunit is found in two isoforms in the skeletal muscle: a minor form of 212 kDa containing the complete amino acid sequence, and a major form of 190 kDa derived from the full-length form by post-translational proteolysis close to Phe-1690. Phosphorylated. Phosphorylation by PKA activates the calcium channel. Both the minor and major forms are phosphorylated in vitro by PKA. Phosphorylation at Ser-1575 is involved in beta-adrenergic-mediated regulation of the channel.
Function Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcplasmic reticulum and ultimately results in muscle contraction. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group.
Protein Name Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1s
Calcium Channel - L Type - Alpha-1 Polypeptide - Isoform 3 - Skeletal Muscle
Dihydropyridine Receptor
Dhpr
Voltage-Gated Calcium Channel Subunit Alpha Cav1.1
Database Links
Cellular Localisation Cell Membrane
Sarcolemma
T-Tubule
Multi-Pass Membrane Protein
Alternative ELISA Names Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1s ELISA kit
Calcium Channel - L Type - Alpha-1 Polypeptide - Isoform 3 - Skeletal Muscle ELISA kit
Dihydropyridine Receptor ELISA kit
Dhpr ELISA kit
Voltage-Gated Calcium Channel Subunit Alpha Cav1.1 ELISA kit
Cacna1s ELISA kit
Cach1 ELISA kit
Cach1b ELISA kit
Cacn1 ELISA kit
Cacnl1a3 ELISA kit
output

Information sourced from Uniprot.org

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