| Post Translational Modifications | Proteolytic cleavage of the N-terminus removes the signal-anchor and produces a soluble form of the protein. N-glycosylated. Required for enzyme activity. O-glycosylated. Required to retain it as a type II membrane protein at the cell surface. Phosphorylated. May prevent ubiquitination and subsequent degradation. Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is triggered by nitric oxide. |
| Function | Plasma membrane ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at neutral pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine. Together with sphingomyelinase, participates in the production of sphingosine and sphingosine-1-phosphate from the degradation of sphingomyelin, a sphingolipid enriched in the plasma membrane of cells. Also participates in the hydrolysis of ceramides from the extracellular milieu allowing the production of sphingosine-1-phosphate inside and outside cells. This is the case for instance with the digestion of dietary sphingolipids in the intestinal tract. |
| Protein Name | Neutral CeramidaseN-CdaseNcdaseAcylsphingosine Deacylase 2N-Acylsphingosine Amidohydrolase 2 Cleaved Into - Neutral Ceramidase Soluble Form |
| Database Links | Reactome: R-MMU-9840310 |
| Cellular Localisation | Neutral Ceramidase: Cell MembraneSingle-Pass Type Ii Membrane ProteinMembrane RaftMembraneCaveolaGolgi Apparatus MembraneMitochondrionSecretedExtracellular ExosomeEnriched In Exosomes Upon Stimulation By CytokineEnriched In Caveolae And Lipid RaftsNeutral Ceramidase Soluble Form: Secreted |
| Alternative Protein Names | Neutral Ceramidase proteinN-Cdase proteinNcdase proteinAcylsphingosine Deacylase 2 proteinN-Acylsphingosine Amidohydrolase 2 Cleaved Into - Neutral Ceramidase Soluble Form proteinAsah2 protein |
Information sourced from Uniprot.org
