| Tissue Specificity | Detected at the luminal membrane of secretory epithelial cells in hindpaw sweat glands. Detected in acinar cells in salivary glands, in duct cells in lacrimal glands and in lung (at protein level). Detected in lung, parotid, submandibular, sublingual, and lacrimal gland tissues. |
| Post Translational Modifications | |
| Function | Aquaporins form homotetrameric transmembrane channels, with each monomer independently mediating water transport across the plasma membrane along its osmotic gradient. Plays an important role in fluid secretion in salivary glands. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells. Seems to play a redundant role in water transport in the eye, lung and in sweat glands. |
| Protein Name | Aquaporin-5Aqp-5 |
| Database Links | Reactome: R-MMU-432047 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinCell MembraneCytoplasmic Vesicle MembraneHypotonicity Increases Location At The Cell MembranePhosphorylation Decreases Location At The Cell Membrane |
| Alternative ELISA Names | Aquaporin-5 ELISA kitAqp-5 ELISA kitAqp5 ELISA kit |
| output | |
Information sourced from Uniprot.org
