Mouse ACAT2 (Acetyl Coenzyme A Acetyltransferase 2) Sandwich ELISA Kit Ready-To-Use Kit (STJE0013214)

Mouse ACAT2 (Acetyl Coenzyme A Acetyltransferase 2) Sandwich ELISA Kit Ready-To-Use Kit (STJE0013214)

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STJE0013214
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Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.047ng/mL
Detection Limit: 0.156-10ng/mL
Short Description : This ACAT2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse tissue homogenates, cell lysates or other biological fluids..
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Soat2
Gene ID: 223920
Uniprot ID: SOAT2_MOUSE
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity
Post Translational Modifications Polyubiquitinated by AMFR/gp78 at Cys-280, leading to its degradation when the lipid levels are low. Association with AMFR/gp78 is mediated via interaction with INSIG1. High concentration of cholesterol and fatty acid results in Cys-280 oxidation, preventing ubiquitination at the same site, resulting in protein stabilization. Oxidized at Cys-280: high concentration of cholesterol and fatty acid induce reactive oxygen species, which oxidizes Cys-280, preventing ubiquitination at the same site, and resulting in protein stabilization.
Function Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) and linolenoyl-CoA ((9Z,12Z,15Z)-octadecatrienoyl-CoA) as substrates. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa.
Protein Name Sterol O-Acyltransferase 2
Acyl-Coenzyme A -Cholesterol Acyltransferase 2
Acat-2
Cholesterol Acyltransferase 2
Database Links Reactome: R-MMU-8964038
Cellular Localisation Endoplasmic Reticulum Membrane
Multi-Pass Membrane Protein
Alternative ELISA Names Sterol O-Acyltransferase 2 ELISA kit
Acyl-Coenzyme A -Cholesterol Acyltransferase 2 ELISA kit
Acat-2 ELISA kit
Cholesterol Acyltransferase 2 ELISA kit
Soat2 ELISA kit
Acact-2 ELISA kit
Acat2 ELISA kit
output

Information sourced from Uniprot.org

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