Human TRIM16 protein (Recombinant) (N-His) (STJP007875)

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STJP007875
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human TRIM16-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: TRIM16
Gene ID: 10626
Uniprot ID: TRI16_HUMAN
Immunogen Region: Lys384-Pro564
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated by ULK1. Auto-ubiquitinates via its B-Boxes.
Function E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage.
Protein Name Tripartite Motif-Containing Protein 16
E3 Ubiquitin-Protein Ligase Trim16
Estrogen-Responsive B Box Protein
Cellular Localisation Cytoplasm
Alternative Protein Names Tripartite Motif-Containing Protein 16 protein
E3 Ubiquitin-Protein Ligase Trim16 protein
Estrogen-Responsive B Box Protein protein
TRIM16 protein
EBBP protein

Information sourced from Uniprot.org

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