Name: Human TNFSF14/LIGHT/HVEM-L/CD258 protein (Recombinant) (N-his) (STJP001331)
SKU: STJP001331
Availability: InStock

Human TNFSF14/LIGHT/HVEM-L/CD258 protein (Recombinant) (N-his) (STJP001331)

SKU:

STJP001331

£89.50 - £274.50

Host:	HEK293 cells
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Formulation:	Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method:	Please contact us for more information.
Immunoreactivity:	Measured by its binding ability in a functional ELISA. Immobilized Human TNFSF14 at 2 Mu g/mL (100 Mu L/well) can bind Mouse HVEM with a linear range of 0.02-0.89 Mu g/mL.

Gene Symbol:	TNFSF14
Gene ID:	8740
Uniprot ID:	TNF14_HUMAN
Immunogen:	Recombinant Human TNFSF14/LIGHT/HVEM-L/CD258 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asp74-Val240) of Human TNFSF14 (Accession #NP_003798.2) fused with a 6×His tag at the N-terminus.
Immunogen Sequence:	DGPAGSWEQLIQERRSHEVN PAAHLTGANSSLTGSGGPLL WETQLGLAFLRGLSYHDGAL VVTKAGYYYIYSKVQLGGV GCPLGLASTITHGLYKRTPR YPEELELLVSQQSPCGRATS S SRVWWDSSFLGGVVHLEA GEKVVVRVLDERLVRLRDGT RSYFGAFMV

Post Translational Modifications	N-glycosylated. The soluble form of isoform 1 derives from the membrane form by proteolytic processing.
Function	Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Acts as a ligand for TNFRSF14/HVEM. Upon binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells, leading to T cell proliferation and IFNG production.
Protein Name	Tumor Necrosis Factor Ligand Superfamily Member 14 Herpes Virus Entry Mediator Ligand Hvem-L Herpesvirus Entry Mediator Ligand Cd Antigen Cd258 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 14 - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 14 - Soluble Form
Database Links	Reactome: R-HSA-5668541 Reactome: R-HSA-5669034 Reactome: R-HSA-5676594
Cellular Localisation	Tumor Necrosis Factor Ligand Superfamily Member 14 Membrane Form: Cell Membrane Single-Pass Type Ii Membrane Protein Soluble Form: Secreted Isoform 2: Cytoplasm
Alternative Protein Names	Tumor Necrosis Factor Ligand Superfamily Member 14 protein Herpes Virus Entry Mediator Ligand protein Hvem-L protein Herpesvirus Entry Mediator Ligand protein Cd Antigen Cd258 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 14 - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 14 - Soluble Form protein TNFSF14 protein HVEML protein LIGHT protein UNQ391 protein PRO726 protein

Information sourced from Uniprot.org

Model	Name	Host
STJP000846	Human TNFRSF14/HVEM/CD270 protein (Recombinant) (C-hFc&His) (STJP000846)	HEK293 cells
STJP002629	Human FABP1/L-FABP protein (Recombinant) (N-His) (STJP002629)	HEK293 cells
STJP003027	Human CCL3L1 protein (Recombinant) (N-His) (STJP003027)	HEK293 cells
STJP002980	Human KLHL20 protein (Recombinant) (N-His) (STJP002980)	HEK293 cells
STJP001380	Human TET2 protein (Recombinant) (N-his) (STJP001380)	HEK293 cells

Human TNFSF14/LIGHT/HVEM-L/CD258 protein (Recombinant) (N-his) (STJP001331)