• Biotinylated Human TIGIT on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
  • The purity of Biotinylated Human TIGIT is greater than 95% as determined by SEC-HPLC.
  • Immobilized Biotinylated Human TIGIT, His Tag at 0. 5 Mu g/ml (100 Mu l/well) on the streptavidin precoated plate (5 Mu g/ml). Dose response curve for Human CD155, hFc Tag with the EC50 of 8. 7ng/ml determined by ELISA.

Human TIGIT protein (Recombinant) (C-His-Avi) {Biotin} (STJP001722)

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STJP001722

£618.50 - £1,909.50
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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human TIGIT-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range: Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction: The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol: TIGIT
Gene ID: 201633
Uniprot ID: TIGIT_HUMAN
Immunogen Region: Met22-Pro141
Immunogen: DNA sequence encoding Human TIGIT including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Function Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
Protein Name T-Cell Immunoreceptor With Ig And Itim Domains
V-Set And Immunoglobulin Domain-Containing Protein 9
V-Set And Transmembrane Domain-Containing Protein 3
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names T-Cell Immunoreceptor With Ig And Itim Domains protein
V-Set And Immunoglobulin Domain-Containing Protein 9 protein
V-Set And Transmembrane Domain-Containing Protein 3 protein
TIGIT protein
VSIG9 protein
VSTM3 protein

Information sourced from Uniprot.org

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