Tissue Specificity | Detected on kidney podocytes along the glomerular capillary wall (at protein level). |
Post Translational Modifications | Proteolytic cleavage in the extracellular region generates a 210 kDa soluble form. Extensively N-glycosylated. |
Function | Thrombospondin type-1 domain-containing protein 7A: Plays a role in actin cytoskeleton rearrangement. Thrombospondin type-1 domain-containing protein 7A, soluble form: The soluble form promotes endothelial cell migration and filopodia formation during sprouting angiogenesis via a FAK-dependent mechanism. |
Protein Name | Thrombospondin Type-1 Domain-Containing Protein 7a Cleaved Into - Thrombospondin Type-1 Domain-Containing Protein 7a - Soluble Form |
Database Links | Reactome: R-HSA-5083635Reactome: R-HSA-5173214 |
Cellular Localisation | Thrombospondin Type-1 Domain-Containing Protein 7a: Cell MembraneSingle-Pass Type I Membrane ProteinCell ProjectionDetected On Podocyte Foot ProcessesThrombospondin Type-1 Domain-Containing Protein 7aSoluble Form: SecretedProteolytic Cleavage In The Extracellular Region Generates A 210 Kda Soluble Form |
Alternative ELISA Names | Thrombospondin Type-1 Domain-Containing Protein 7a Cleaved Into - Thrombospondin Type-1 Domain-Containing Protein 7a - Soluble Form ELISA kitTHSD7A ELISA kitKIAA0960 ELISA kit |
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Information sourced from Uniprot.org