Human SYTL2 (Synaptotagmin Like Protein 2) Sandwich ELISA Kit Ready-To-Use Kit (STJE0018804)

Human SYTL2 (Synaptotagmin Like Protein 2) Sandwich ELISA Kit Ready-To-Use Kit (STJE0018804)

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STJE0018804
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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.113ng/mL
Detection Limit: 0.312-20ng/mL
Short Description : This SYTL2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates, cell lysates or other biological fluids..
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: SYTL2
Gene ID: 54843
Uniprot ID: SYTL2_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Isoform 1 is expressed in hematopoietic lineages with a strong expression in CD4 and CD8 T-lymphocytes. It is also widely expressed in nonhematopoietic tissues. Isoform 5 is expressed only in nonhematopoietic tissues. Isoform 4 is expressed in pancreatic alpha cells.
Post Translational Modifications Isoform 1 is highly susceptible to proteolytic degradation and is stabilized by the interaction with RAB27A.
Function Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive.
Protein Name Synaptotagmin-Like Protein 2
Breast Cancer-Associated Antigen Sga-72m
Exophilin-4
Database Links Reactome: R-HSA-9824585
Cellular Localisation Isoform 1: Cytoplasm
Cell Membrane
Recruited On Vesicular Structures In Cytotoxic T-Lymphocytes (Ctl) By Rab27a
Isoform 4: Cell Membrane
In The Pancreatic Alpha Cells Distributed In Both Peripheral And Anterior Regions
Localizes On The Glucagon Granules In The Cell Periphery
Alternative ELISA Names Synaptotagmin-Like Protein 2 ELISA kit
Breast Cancer-Associated Antigen Sga-72m ELISA kit
Exophilin-4 ELISA kit
SYTL2 ELISA kit
KIAA1597 ELISA kit
SGA72M ELISA kit
SLP2 ELISA kit
SLP2A ELISA kit
output

Information sourced from Uniprot.org

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