Human SYCP3 protein (Recombinant) (N-His) (STJP009666)

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STJP009666
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SYCP3-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SYCP3
Gene ID: 50511
Uniprot ID: SYCP3_HUMAN
Immunogen Region: Lys83-Phe236
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated.
Function Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in male germ cells. Required for normal meiosis during spermatogenesis and male fertility. Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2.
Protein Name Synaptonemal Complex Protein 3
Scp-3
Database Links Reactome: R-HSA-1221632
Cellular Localisation Nucleus
Chromosome
Centromere
It Is Present In Early Unpaired Cores
In The Lateral Domains Of The Synaptonemal Complex And In The Chromosome Cores When They Separate At Diplotene
It Is Found Axial To The Metaphase I Chromosomes And In Association With Pairs Of Sister Centromeres
The Centromere-Associated Protein Becomes Dissociated From The Centromeres At Anaphase Ii And Is Not Found In Mitotic Metaphase Centromeres
Alternative Protein Names Synaptonemal Complex Protein 3 protein
Scp-3 protein
SYCP3 protein
SCP3 protein

Information sourced from Uniprot.org

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