| Tissue Specificity | Widely expressed. Expressed in human tumor cell lines. Isoform 4 is only found in an embryonal kidney cell line. |
| Post Translational Modifications | |
| Function | Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal. |
| Protein Name | Spermine OxidasePolyamine Oxidase 1Pao-1Paoh1 |
| Database Links | Reactome: R-HSA-141334 Q9NWM0-3Reactome: R-HSA-351200 Q9NWM0-3 |
| Cellular Localisation | Isoform 1: CytoplasmNucleusIsoform 4: CytoplasmIsoform 6: Cytoplasm |
| Alternative ELISA Names | Spermine Oxidase ELISA kitPolyamine Oxidase 1 ELISA kitPao-1 ELISA kitPaoh1 ELISA kitSMOX ELISA kitC20orf16 ELISA kitSMO ELISA kitUNQ3039 ELISA kitPRO9854 ELISA kit |
| output | |
Information sourced from Uniprot.org
