| Function | Na(+)-independent transporter that mediates the cellular uptake of a broad range of organic anions such as the endogenous bile salts cholate and deoxycholate, either in their unconjugated or conjugated forms (taurocholate and glycocholate), at the plasmam membrane. Responsible for intestinal absorption of bile acids. Transports dehydroepiandrosterone 3-sulfate (DHEAS), a major circulating steroid secreted by the adrenal cortex, as well as estrone 3-sulfate and 17beta-estradiol 17-O-(beta-D-glucuronate). Mediates apical uptake of all-trans-retinol (atROL) across human retinal pigment epithelium, which is essential to maintaining the integrity of the visual cycle and thus vision. Involved in the uptake of clinically used drugs. Capable of thyroid hormone transport (both T3 or 3,3',5'-triiodo-L-thyronine, and T4 or L-tyroxine). Also transports prostaglandin E2. Plays roles in blood-brain and -cerebrospinal fluid barrier transport of organic anions and signal mediators, and in hormone uptake by neural cells. May also play a role in the reuptake of neuropeptides such as substance P/TAC1 and vasoactive intestinal peptide/VIP released from retinal neurons. May play an important role in plasma and tissue distribution of the structurally diverse chemotherapeutic drugs methotrexate and paclitaxel. Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment. Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions. May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable). |
| Protein Name | Solute Carrier Organic Anion Transporter Family Member 1a2Oatp1a2Oatp-AOrganic Anion-Transporting Polypeptide 1Oatp-1Sodium-Independent Organic Anion TransporterSolute Carrier Family 21 Member 3 |
| Database Links | Reactome: R-HSA-159418Reactome: R-HSA-879518Reactome: R-HSA-9793528 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasal Cell MembraneLocalized To The Basal Membrane Of Sertoli Cells |
| Alternative Protein Names | Solute Carrier Organic Anion Transporter Family Member 1a2 proteinOatp1a2 proteinOatp-A proteinOrganic Anion-Transporting Polypeptide 1 proteinOatp-1 proteinSodium-Independent Organic Anion Transporter proteinSolute Carrier Family 21 Member 3 proteinSLCO1A2 proteinOATP proteinOATP1 proteinOATP1A2 proteinSLC21A3 protein |
Information sourced from Uniprot.org
