Human RTN4R/NgR1/Nogor protein (Recombinant-Active) (C-hFc-His) (STJP012250)

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STJP012250-100
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Active-Human RTN4R/NgR1/Nogor-C-hFc-His protein was developed from mammalian cells and has a target region of C-hFc-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: <0.1 EU/Mu g of the protein by the LAL method.
Gene Symbol: RTN4R
Gene ID: 65078
Uniprot ID: RTN4R_HUMAN
Immunogen Region: Cys27-Ser447
Immunogen: Homo sapiens (Human)
Post Translational Modifications N-glycosylated. O-glycosylated. Contains terminal sialic acid groups on its glycan chains.
Function Receptor for RTN4, OMG and MAG. Functions as a receptor for the sialylated gangliosides GT1b and GM1. Besides, functions as a receptor for chondroitin sulfate proteoglycans. Can also bind heparin. Intracellular signaling cascades are triggered via the coreceptor NGFR. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. Mediates axonal growth inhibition. Plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis.protection against apoptosis is probably mediated via interaction with MAG. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development.
Protein Name Reticulon-4 Receptor
Nogo Receptor
Ngr
Nogo-66 Receptor
Database Links Reactome: R-HSA-193634
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Membrane Raft
Cell Projection
Dendrite
Axon
Perikaryon
Detected Along Dendrites And Axons
Close To Synapses
But Clearly Excluded From Synapses
Alternative Protein Names Reticulon-4 Receptor protein
Nogo Receptor protein
Ngr protein
Nogo-66 Receptor protein
RTN4R protein
NOGOR protein
UNQ330 protein
PRO526 protein

Information sourced from Uniprot.org