Human RSAD2 protein (Recombinant) (N-His) (STJP007648)

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STJP007648
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human RSAD2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: RSAD2
Gene ID: 91543
Uniprot ID: RSAD2_HUMAN
Immunogen Region: Ser74-Trp361
Immunogen: Homo sapiens (Human)
Function Interferon-inducible antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Catalyzes the conversion of cytidine triphosphate (CTP) to 3'-deoxy-3',4'-didehydro-CTP (ddhCTP) via a SAM-dependent radical mechanism. In turn, ddhCTP acts as a chain terminator for the RNA-dependent RNA polymerases from multiple viruses and directly inhibits viral replication. Therefore, inhibits a wide range of DNA and RNA viruses, including human cytomegalovirus (HCMV), hepatitis C virus (HCV), west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus, vesicular stomatitis virus (VSV), zika virus, and human immunodeficiency virus (HIV-1). Promotes also TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating 'Lys-63'-linked ubiquitination of IRAK1 by TRAF6. Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor (TCR)-mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins.
Protein Name S-Adenosylmethionine-Dependent Nucleotide Dehydratase Rsad2
Sand
Cytomegalovirus-Induced Gene 5 Protein
Radical S-Adenosyl Methionine Domain-Containing Protein 2
Virus Inhibitory Protein - Endoplasmic Reticulum-Associated - Interferon-Inducible
Viperin
Database Links Reactome: R-HSA-909733
Cellular Localisation Endoplasmic Reticulum Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Golgi Apparatus
Endoplasmic Reticulum
Lipid Droplet
Mitochondrion
Mitochondrion Inner Membrane
Mitochondrion Outer Membrane
Infection With Human Cytomegalovirus (Hcmv) Causes Relocation To The Golgi Apparatus And To Cytoplasmic Vacuoles Which Also Contain Hcmv Proteins Glycoprotein B And Pp28
Interaction With Human Cytomegalovirus/Hhv-5 Protein Vmia/Ul37 Results In Its Relocalization From The Endoplasmic Reticulum To The Mitochondria
Alternative Protein Names S-Adenosylmethionine-Dependent Nucleotide Dehydratase Rsad2 protein
Sand protein
Cytomegalovirus-Induced Gene 5 Protein protein
Radical S-Adenosyl Methionine Domain-Containing Protein 2 protein
Virus Inhibitory Protein - Endoplasmic Reticulum-Associated - Interferon-Inducible protein
Viperin protein
RSAD2 protein
CIG5 protein

Information sourced from Uniprot.org

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