Human REXO2 protein (Recombinant) (N-His) (STJP006256)

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STJP006256
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human REXO2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: REXO2
Gene ID: 25996
Uniprot ID: ORN_HUMAN
Immunogen Region: Gln41-Asn213
Immunogen: Homo sapiens (Human)
Function 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides. Binds and degrades longer oligonucleotides with a lower affinity. Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing. Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome. Essential for embryonic development. Isoform 3: 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides.
Protein Name Oligoribonuclease - Mitochondrial
Rna Exonuclease 2 Homolog
Small Fragment Nuclease
Database Links Reactome: R-HSA-9836573
Cellular Localisation Mitochondrion Intermembrane Space
Mitochondrion Matrix
Mitochondrion
Cytoplasm
Nucleus
Isoform 3: Cytoplasm
Alternative Protein Names Oligoribonuclease - Mitochondrial protein
Rna Exonuclease 2 Homolog protein
Small Fragment Nuclease protein
REXO2 protein
SFN protein
SMFN protein
CGI-114 protein

Information sourced from Uniprot.org