| Post Translational Modifications | Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity. |
| Function | Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. Acts as a hormone in response to different stimuli like anti-inflammatory signals, such as IL17A, or gut microbiome. Is secreted by different cell types to activate its receptor EXTL3 and induce cell specific signaling pathways. Induced by IL17A in keratinocytes, regulates keratinocyte proliferation and differentiation after skin injury. In parallel, inhibits skin inflammation through the inhibition of inflammatory cytokines such as IL6 and TNF. Induced by IL22 in lung epithelial cells, inhibits cytokine production and regulates allergic airway inflammation. Induced in small intestine by inulin-enriched diet and Lactobacillus gasseri enriched microbiome, plays a role in the improvement of gut barrier function, the regulation of energy balance and glucose levels. Modulates microbiota composition in duodenal contents. Produced by nociceptor in response to endotoxins, prevents endotoxic death by targeting kynurenine pathway in microglia. Regenerating islet-derived protein 3-gamma 16.5 kDa form: Has bacteriostatic activity. Regenerating islet-derived protein 3-gamma 15 kDa form: Has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. |
| Protein Name | Regenerating Islet-Derived Protein 3-GammaReg-3-GammaPancreatitis-Associated Protein 1bPap-1bPancreatitis-Associated Protein IbPap IbRegenerating Islet-Derived Protein Iii-GammaReg IiiReg Iii-Gamma Cleaved Into - Regenerating Islet-Derived Protein 3-Gamma 16.5 Kda Form - Regenerating Islet-Derived Protein 3-Gamma 15 Kda Form |
| Database Links | Reactome: R-HSA-6803157 |
| Cellular Localisation | SecretedCytoplasm |
| Alternative Protein Names | Regenerating Islet-Derived Protein 3-Gamma proteinReg-3-Gamma proteinPancreatitis-Associated Protein 1b proteinPap-1b proteinPancreatitis-Associated Protein Ib proteinPap Ib proteinRegenerating Islet-Derived Protein Iii-Gamma proteinReg Iii proteinReg Iii-Gamma Cleaved Into - Regenerating Islet-Derived Protein 3-Gamma 16.5 Kda Form - Regenerating Islet-Derived Protein 3-Gamma 15 Kda Form proteinREG3G proteinPAP1B proteinUNQ429 proteinPRO162 protein |
Information sourced from Uniprot.org
