| Post Translational Modifications | Phosphorylated by HSV-1 protein kinases in case of infection. |
| Function | Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. |
| Protein Name | Rest Corepressor 1Protein Corest |
| Database Links | Reactome: R-HSA-3214815Reactome: R-HSA-8943724Reactome: R-HSA-9679191Reactome: R-HSA-983231 |
| Cellular Localisation | NucleusUpon Infection By Hsv-1It Is Partially Translocated Into The Cytoplasm In An Hsv-1-Dependent Manner |
| Alternative Protein Names | Rest Corepressor 1 proteinProtein Corest proteinRCOR1 proteinKIAA0071 proteinRCOR protein |
Information sourced from Uniprot.org
