| Post Translational Modifications | Phosphorylated at multiple sites in the midbody during cytokinesis. Phosphorylation by AURKB on Ser-387 at the midbody is, at least in part, responsible for exerting its latent GAP activity towards RhoA. Phosphorylation on multiple serine residues by PLK1 enhances its association with ECT2 and is critical for cleavage furrow formation. Phosphorylation on Ser-164 plays a major role in mediating interaction with ECT2. Phosphorylation on Ser-157 does not appear to contribute to binding to ECT2. |
| Function | Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Has a critical role in erythropoiesis. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. |
| Protein Name | Rac Gtpase-Activating Protein 1Male Germ Cell RacgapMgcracgapProtein Cyk4 HomologCyk4Hscyk-4 |
| Database Links | Reactome: R-HSA-2132295Reactome: R-HSA-6811434Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013405Reactome: R-HSA-9013423Reactome: R-HSA-983189 |
| Cellular Localisation | NucleusCytoplasmCytoskeletonSpindleCytoplasmic VesicleSecretory VesicleAcrosomeCleavage FurrowMidbodyMidbody RingCell MembranePeripheral Membrane ProteinCytoplasmic SideColocalizes With Rnd2 In Golgi-Derived Proacrosomal Vesicles And The AcrosomeDuring InterphaseLocalized To The Nucleus And Cytoplasm Along With MicrotubulesIn AnaphaseIs Redistributed To The Central Spindle AndIn Telophase And CytokinesisTo The Midbody RingAlso Called Flemming BodyColocalizes With Rhoa At The Myosin Contractile Ring During CytokinesisColocalizes With Ect2 To The Mitotic Spindles During Anaphase/MetaphaseThe Cleavage Furrow During Telophase And At The Midbody At The End Of CytokinesisColocalizes With Cdc42 To Spindle Microtubules From Prometaphase To Telophase |
| Alternative Protein Names | Rac Gtpase-Activating Protein 1 proteinMale Germ Cell Racgap proteinMgcracgap proteinProtein Cyk4 Homolog proteinCyk4 proteinHscyk-4 proteinRACGAP1 proteinKIAA1478 proteinMGCRACGAP protein |
Information sourced from Uniprot.org
