Recombinant Human R-spondin-2/RSPO2 Protein was determined by SDS-PAGE under reducing (R)

Human R-spondin-2/RSPO2 protein (Recombinant) (C-hFc) (STJP003062)

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STJP003062
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Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 0.01 EU/Mu g of the protein by LAL method.
Immunoreactivity: Measured by its ability to induce Topflash reporter activity in 293 human embryonic kidney cells. The typical ED50 is 86 ng/mL in the presence of 3.24 ng/mL Recombinant Human Wnt3a Surrogate.
Gene Symbol: RSPO2
Gene ID: 340419
Uniprot ID: RSPO2_HUMAN
Immunogen Region: Ala32-Gly205
Immunogen: Recombinant Human R-spondin-2/RSPO2 Protein is produced by Mammalian expression system. The target protein is expressed with sequence (Ala32-Gly205) of human R-spondin-2 (Accession #Q6UXX9) fused with hFc tag at the C-terminus.
Immunogen Sequence: VTSAGPEESDGDLSCVCVKT ISSGIHLKHITSLEVIKAGR HCAVPQLIATLKNGRKICLD RQAPLYKKVIKKILES
Function Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form.
Protein Name R-Spondin-2
Roof Plate-Specific Spondin-2
Hrspo2
Database Links Reactome: R-HSA-4641263
Cellular Localisation Secreted
Alternative Protein Names R-Spondin-2 protein
Roof Plate-Specific Spondin-2 protein
Hrspo2 protein
RSPO2 protein
UNQ9384 protein
PRO34209 protein

Information sourced from Uniprot.org

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