Human PIP4K2B/PIP4KII-beta protein (Recombinant) (N-His) (STJP009974)

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STJP009974
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PIP4K2B/PIP4KII-beta-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PIP4K2B
Gene ID: 8396
Uniprot ID: PI42B_HUMAN
Immunogen Region: Ser2-Thr416
Immunogen: Homo sapiens (Human)
Post Translational Modifications Ubiquitinated by the SPOP/CUL3 complex. Ubiquitination is stimulated by PtdIns5P levels. Phosphorylated on serine residues.
Function Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration. Its GTP-sensing activity is critical for metabolic adaptation. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3.
Protein Name Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Beta
1-Phosphatidylinositol 5-Phosphate 4-Kinase 2-Beta
Diphosphoinositide Kinase 2-Beta
Phosphatidylinositol 5-Phosphate 4-Kinase Type Ii Beta
Pi(5p 4-Kinase Type Ii Beta
Pip4kii-Beta
Ptdins(5p-4-Kinase Isoform 2-Beta
Database Links Reactome: R-HSA-1660499
Reactome: R-HSA-6811555
Reactome: R-HSA-6811558
Reactome: R-HSA-8847453
Cellular Localisation Endoplasmic Reticulum Membrane
Peripheral Membrane Protein
Cell Membrane
Nucleus
Cytoplasm
Associated With The Plasma Membrane And The Endoplasmic Reticulum
Alternative Protein Names Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Beta protein
1-Phosphatidylinositol 5-Phosphate 4-Kinase 2-Beta protein
Diphosphoinositide Kinase 2-Beta protein
Phosphatidylinositol 5-Phosphate 4-Kinase Type Ii Beta protein
Pi(5p 4-Kinase Type Ii Beta protein
Pip4kii-Beta protein
Ptdins(5p-4-Kinase Isoform 2-Beta protein
PIP4K2B protein
PIP5K2B protein

Information sourced from Uniprot.org

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