Name: Human Phospholipase A2/PLA2G1B protein (Recombinant) (C-His) (STJP003076)
SKU: STJP003076
Availability: InStock

General Information
Product Properties
Target Information
Additional Info
Product Review

Host:	HEK293 cells
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Formulation:	Lyophilised from a 0.22 Mu m filtered solution of 10 mM Tris, 5 mM CaCl₂, pH 8.0.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method:	< 1.0 EU/Mu g of the protein by LAL method.
Immunoreactivity:	Measured by its ability to hydrolyze 1-Hexadecanoyl-2- (1-pyrenedecanoyl)-sn-glycero-3-phosphomethanol. The specific activity is >2500 pmol/min/Mu g.

Gene Symbol:	PLA2G1B
Gene ID:	5319
Uniprot ID:	PA21B_HUMAN
Immunogen Region:	Met1-Ser148
Immunogen:	Recombinant Human Phospholipase A2/PLA2G1B Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Ser148) of human Phospholipase A2/PLA2G1B (Accession #NP_000919.1) fused with His tag at the C-termi
Immunogen Sequence:	AVAEMNPNVNVFVPPRDGFS GPAPRKSKLICEATNFTPKP ITVSWLKDGKLVESGFTTDP VTIENKGSTPQTYKVISTLT ISEIDWLNLNVYTCRVDHRG LTFLKNVSSTCAASPSTDIL TFTIPPSFADIFLSKSANLT CLVSNLATYETLNISWASQS GEPLETKIKIMESHPNGTFS AKGVASVCVEDWNNRKEFVC TVTHRDLPSPQKKFISKPNE VHKHPPAVYLLPPAREQLN

Tissue Specificity	Selectively expressed in pancreas, lung, liver and kidney. Also detected at lower levels in ovary and testis.
Post Translational Modifications	Activated by trypsin cleavage in the duodenum. Can also be activated by thrombin or autocatalytically.
Function	Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines. May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines. May act in an autocrine and paracrine manner. Upon binding to the PLA2R1 receptor can regulate podocyte survival and glomerular homeostasis. Has anti-helminth activity in a process regulated by gut microbiota. Upon helminth infection of intestinal epithelia, directly affects phosphatidylethanolamine contents in the membrane of helminth larvae, likely controlling an array of phospholipid-mediated cellular processes such as membrane fusion and cell division while providing for better immune recognition, ultimately reducing larvae integrity and infectivity.
Protein Name	Phospholipase A2 Group Ib Phospholipase A2 Phosphatidylcholine 2-Acylhydrolase 1b
Database Links	Reactome: R-HSA-1482788 Reactome: R-HSA-1482801 Reactome: R-HSA-1482839 Reactome: R-HSA-1482922 Reactome: R-HSA-1482925 Reactome: R-HSA-1483166
Cellular Localisation	Secreted Secreted From Pancreatic Acinar Cells In Its Inactive Form
Alternative Protein Names	Phospholipase A2 protein Group Ib Phospholipase A2 protein Phosphatidylcholine 2-Acylhydrolase 1b protein PLA2G1B protein PLA2 protein PLA2A protein PPLA2 protein

Information sourced from Uniprot.org

Model	Name	Host
STJP001507	Mouse Ephrin-A2/EFNA2 protein (Recombinant) (C-His) (STJP001507)	HEK293 cells
STJP001089	Human CD14 protein (Recombinant) (C-His) (STJP001089)	HEK293 cells
STJP000795	Human BID protein (Recombinant) (C-His) (STJP000795)	E. coli
STJP002706	Human MPO protein (Recombinant) (C-His) (STJP002706)	HEK293 cells
STJP001297	Human CD47 protein (Recombinant) (C-His) (STJP001297)	HEK293 cells

Human Phospholipase A2/PLA2G1B protein (Recombinant) (C-His) (STJP003076)

Related Products