| Host: | Mouse/Mouse |
| Applications: | ELISA |
| Reactivity: | Human |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description : | This PAPPA antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Clonality : | Monoclonal/Monoclonal |
| Conjugation: | Unconjugated/Biotin |
| Formulation: | Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4. |
| Purification: | Capture Purification: Protein A or G.Detection Purification: Protein A or G. |
| Concentration: | 0.5 mg/mL |
| Storage Instruction: | Store at-20°C for long term, and avoid freeze-thaw cycles. |
| Gene Symbol: | PAPPA |
| Gene ID: | 5069 |
| Uniprot ID: | PAPP1_HUMAN |
| Immunogen: | Capture immunogen: Recombinant Human PAPPA protein.Detection Immunogen: Recombinant Human PAPPA protein. |
| Post Translational Modifications | There appear to be no free sulfhydryl groups. |
| Function | Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. |
| Protein Name | Pappalysin-1Insulin-Like Growth Factor-Dependent Igf-Binding Protein 4 ProteaseIgf-Dependent Igfbp-4 ProteaseIgfbp-4asePregnancy-Associated Plasma Protein APapp-A |
| Database Links | Reactome: R-HSA-381426 |
| Cellular Localisation | Secreted |
| Alternative Antibody Pair Names | Pappalysin-1 antibody pairInsulin-Like Growth Factor-Dependent Igf-Binding Protein 4 Protease antibody pairIgf-Dependent Igfbp-4 Protease antibody pairIgfbp-4ase antibody pairPregnancy-Associated Plasma Protein A antibody pairPapp-A antibody pairPAPPA antibody pair |
Information sourced from Uniprot.org