Human PACSIN2 protein (Recombinant) (N-GST & C-His) (STJP008817)

SKU:
STJP008817
€410.63 - €1,796.88
Free Shipping
Processing The item has been added

Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PACSIN2-N-GST & C-His protein was developed from e. coli and has a target region of N-GST & C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PACSIN2
Gene ID: 11252
Uniprot ID: PACN2_HUMAN
Immunogen Region: Ser425-Gln486
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated by casein kinase 2 (CK2). Phosphorylation by PKC probably decreases the membrane binding and tubulation capacities of PACSIN2, thereby modulating the lifetime of caveolae.
Function Regulates the morphogenesis and endocytosis of caveolae. Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. (Microbial infection) Specifically enhances the efficiency of HIV-1 virion spread by cell-to-cell transfer. Also promotes the protrusion engulfment during cell-to-cell spread of bacterial pathogens like Listeria monocytogenes. Involved in lipid droplet formation, which is important for HCV virion assembly.
Protein Name Protein Kinase C And Casein Kinase Substrate In Neurons Protein 2
Syndapin-2
Syndapin-Ii
Sdpii
Database Links Reactome: R-HSA-8856828
Cellular Localisation Cytoplasm
Cytoskeleton
Cytoplasmic Vesicle Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Early Endosome
Recycling Endosome Membrane
Cell Projection
Ruffle Membrane
Cell Membrane
Membrane
Caveola
Detected At The Neck Of Flask-Shaped Caveolae
Localization To Tubular Recycling Endosomes Probably Requires Interaction With Micall1 And Ehd1
Alternative Protein Names Protein Kinase C And Casein Kinase Substrate In Neurons Protein 2 protein
Syndapin-2 protein
Syndapin-Ii protein
Sdpii protein
PACSIN2 protein

Information sourced from Uniprot.org