Human P4HB protein (Recombinant-Active) (C-10*His) (STJP011816)

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STJP011816-100
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Active-Human P4HB-C-10*His protein was developed from mammalian cells and has a target region of C-10*His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: <0.1 EU/Mu g of the protein by the LAL method.
Gene Symbol: P4HB
Gene ID: 5034
Uniprot ID: PDIA1_HUMAN
Immunogen Region: Asp18-Lys505
Immunogen: Homo sapiens (Human)
Function This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations and following phosphorylation by FAM20C, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9.the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration.
Protein Name Protein Disulfide-Isomerase
Pdi
Cellular Thyroid Hormone-Binding Protein
Prolyl 4-Hydroxylase Subunit Beta
P55
Database Links Reactome: R-HSA-1650814
Reactome: R-HSA-264876
Reactome: R-HSA-3299685
Reactome: R-HSA-381426
Reactome: R-HSA-5358346
Reactome: R-HSA-8866423
Reactome: R-HSA-8957275
Reactome: R-HSA-8963888
Reactome: R-HSA-8964041
Reactome: R-HSA-9020591
Reactome: R-HSA-9020933
Cellular Localisation Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
Melanosome
Cell Membrane
Peripheral Membrane Protein
Highly Abundant
In Some Cell Types
Seems To Be Also Secreted Or Associated With The Plasma Membrane
Where It Undergoes Constant Shedding And Replacement From Intracellular Sources (Probable)
Localizes Near Cd4-Enriched Regions On Lymphoid Cell Surfaces
Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv
Colocalizes With Mttp In The Endoplasmic Reticulum
Alternative Protein Names Protein Disulfide-Isomerase protein
Pdi protein
Cellular Thyroid Hormone-Binding Protein protein
Prolyl 4-Hydroxylase Subunit Beta protein
P55 protein
P4HB protein
ERBA2L protein
PDI protein
PDIA1 protein
PO4DB protein

Information sourced from Uniprot.org