Human NUDT3 protein (Recombinant) (N-His) (STJP010810)

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STJP010810
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human NUDT3-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: NUDT3
Gene ID: 11165
Uniprot ID: NUDT3_HUMAN
Immunogen Region: Gly16-Ser163
Immunogen: Homo sapiens (Human)
Function Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and PP2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphosphate) is not a substrate. Acts as a negative regulator of the ERK1/2 pathway. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A) and diadenosine 5',5'''- P1,P5-pentaphosphate (Ap5A) being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Acts as a decapping enzyme that modulates the stability of a subset of mRNAs implicated in cell motility. Hydrolyzes monomethylated capped RNA after both the alpha- and beta-phosphates generating m7GMP + ppRNA and m7GDP + pRNA. Can hydrolyze unmethylated capped RNAs. Divalent cations zinc, magnesium and manganese determine its substrate specificity. Exhibits diphosphoinositol polyphosphate phosphohydrolase in the presence of magnesium ions, diadenosine hexaphosphate hydrolase activity in the presence of manganese ions and endopolyphosphatase activity in the presence of zinc ions. Plays an important role in limiting DNA damage and maintaining cell survival upon oxidative stress via its endopolyphosphatase activity.
Protein Name Diphosphoinositol Polyphosphate Phosphohydrolase 1
Dipp-1
Diadenosine Hexaphosphate Hydrolase
Ap6a Hydrolase
Endopolyphosphatase
Nucleoside Diphosphate-Linked Moiety X Motif 3
Nudix Motif 3
M7gpppn-Mrna Hydrolase
M7gpppx Diphosphatase
Database Links Reactome: R-HSA-1855167
Cellular Localisation Cytoplasm
Nucleus
Alternative Protein Names Diphosphoinositol Polyphosphate Phosphohydrolase 1 protein
Dipp-1 protein
Diadenosine Hexaphosphate Hydrolase protein
Ap6a Hydrolase protein
Endopolyphosphatase protein
Nucleoside Diphosphate-Linked Moiety X Motif 3 protein
Nudix Motif 3 protein
M7gpppn-Mrna Hydrolase protein
M7gpppx Diphosphatase protein
NUDT3 protein
DIPP protein
DIPP1 protein

Information sourced from Uniprot.org

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