Recombinant Human NKG-2D/KLRK1/CD314 Protein was determined by SDS-PAGE under reducing (R)

Human NKG-2D/KLRK1/CD314 protein (Recombinant) (C-His) (STJP002992)

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STJP002992
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Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: <0.1 EU/Mu g of the protein by LAL method.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Human MICA at 2 Mu g/mL (100 Mu L/well) can bind Human NKG-2D/KLRK1/CD314 with a linear range of 0.005-0.98 Mu g/mL.
Gene Symbol: KLRK1
Gene ID: 100528032/22914
Uniprot ID: NKG2D_HUMAN
Immunogen Region: ILe73-Val216
Immunogen: Recombinant Human NKG-2D/KLRK1/CD314 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (ILe73-Val216) of Human NKG-2D/KLRK1/CD314 (Accession #NP_001186734.1) fused with a hFc at the N-terminus.
Immunogen Sequence: LRRCLISTDMHHIEESFQEI KRAIQAKDTFPNVTILSTLE TLQIIKPLDVCCVTKNLLAF YVDRVFKDHQEPNPKILRKI SSIANSFLYMQKTLRQCQEQ RQCHCRQEATNATRVIHDNY DQLEVHAAAIKSLGELDVFL AWINKNHEVMFSA
Tissue Specificity Expressed in natural killer (NK) cells, CD8(+) alpha-beta and gamma-delta T-cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Expressed in interferon-producing killer dendritic cells (IKDCs).
Function Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.
Protein Name Nkg2-D Type Ii Integral Membrane Protein
Killer Cell Lectin-Like Receptor Subfamily K Member 1
Nk Cell Receptor D
Nkg2-D-Activating Nk Receptor
Cd Antigen Cd314
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-2172127
Reactome: R-HSA-2424491
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Colocalized With Hcst On The Cell Surface
Alternative Protein Names Nkg2-D Type Ii Integral Membrane Protein protein
Killer Cell Lectin-Like Receptor Subfamily K Member 1 protein
Nk Cell Receptor D protein
Nkg2-D-Activating Nk Receptor protein
Cd Antigen Cd314 protein
KLRK1 protein
D12S2489E protein
NKG2D protein

Information sourced from Uniprot.org

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