• Biotinylated Human Nectin-2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
  • The purity of Biotinylated Human Nectin-2 is greater than 95% as determined by SEC-HPLC.
  • Immobilized Biotinylated Human Nectin-2, His Tag at 5 Mu g/ml (100 Mu l/well) on the plate. Dose response curve for Human TIGIT, hFc Tag with the EC50 of 2. 26 Mu g/ml determined by ELISA.

Human Nectin-2/CD112 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001654)

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STJP001654

£618.50 - £1,909.50
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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human Nectin-2/CD112-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range: Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction: The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol: NECTIN2
Gene ID: 5819
Uniprot ID: NECT2_HUMAN
Immunogen Region: Gln32-Leu360
Immunogen: DNA sequence encoding Human Nectin-2/CD112 including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Function Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein. (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).
Protein Name Nectin-2
Herpes Virus Entry Mediator B
Herpesvirus Entry Mediator B
Hveb
Nectin Cell Adhesion Molecule 2
Poliovirus Receptor-Related Protein 2
Cd Antigen Cd112
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-418990
Reactome: R-HSA-420597
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Nectin-2 protein
Herpes Virus Entry Mediator B protein
Herpesvirus Entry Mediator B protein
Hveb protein
Nectin Cell Adhesion Molecule 2 protein
Poliovirus Receptor-Related Protein 2 protein
Cd Antigen Cd112 protein
NECTIN2 protein
HVEB protein
PRR2 protein
PVRL2 protein

Information sourced from Uniprot.org

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