| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human MYO9B-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | MYO9B |
| Gene ID: | 4650 |
| Uniprot ID: | MYO9B_HUMAN |
| Immunogen Region: | Pro1691-Ala1916 |
| Immunogen: | Homo sapiens (Human) |
| Function | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions. Also acts as a GTPase activator for RHOA. Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1.interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA. |
| Protein Name | Unconventional Myosin-IxbUnconventional Myosin-9b |
| Database Links | Reactome: R-HSA-2029482Reactome: R-HSA-8980692Reactome: R-HSA-8985586Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9035034Reactome: R-HSA-9664422 |
| Cellular Localisation | CytoplasmCell CortexPerinuclear RegionCytoskeletonIn Undifferentiated Cells Colocalizes With F-Actin In The Cell Periphery While In Differentiated Cells Its Localization Is Cytoplasmic With The Highest Levels In The Perinuclear Region |
| Alternative Protein Names | Unconventional Myosin-Ixb proteinUnconventional Myosin-9b proteinMYO9B proteinMYR5 protein |
Information sourced from Uniprot.org