| Function | Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis. Minor histocompatibility antigen HA-2: Constitutes the minor histocompatibility antigen HA-2. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. HA-2 is restricted to MHC class I HLA-A*0201. |
| Protein Name | Unconventional Myosin-Ig Cleaved Into - Minor Histocompatibility Antigen Ha-2Mhag Ha-2 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCell ProjectionPhagocytic CupRecruited To Fc-Gamma Receptor (Fc-Gamma-R) Phagocytic CupIn T-CellsTransiently Accumulates In Discrete Areas At The Plasma Membrane Of Migrating Cells Or When Membranes Are DeformedLocalization At The Membrane Is Not Highly Dependent On Phosphatidylinositol 45-Bisphosphate LevelsReleased From The Membrane In The Presence Of AtpMay Be Enriched In Peripheral ProcessesSuch As Microvilli Or Ruffles |
| Alternative Protein Names | Unconventional Myosin-Ig Cleaved Into - Minor Histocompatibility Antigen Ha-2 proteinMhag Ha-2 proteinMYO1G proteinHA2 protein |
Information sourced from Uniprot.org
