Human MOB1B protein (Recombinant) (N-His) (STJP008011)

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STJP008011
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human MOB1B-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: MOB1B
Gene ID: 92597
Uniprot ID: MOB1B_HUMAN
Immunogen Region: Ser23-Arg216
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1.
Function Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.
Protein Name Mob Kinase Activator 1b
Mob1 Homolog 1a
Mob1a
Mob1b
Mps One Binder Kinase Activator-Like 1a
Database Links Reactome: R-HSA-2028269
Cellular Localisation Cytoplasm
Nucleus
Alternative Protein Names Mob Kinase Activator 1b protein
Mob1 Homolog 1a protein
Mob1a protein
Mob1b protein
Mps One Binder Kinase Activator-Like 1a protein
MOB1B protein
MOB4A protein
MOBKL1A protein

Information sourced from Uniprot.org