| Post Translational Modifications | Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1. |
| Function | Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L. |
| Protein Name | Mob Kinase Activator 1bMob1 Homolog 1aMob1aMob1bMps One Binder Kinase Activator-Like 1a |
| Database Links | Reactome: R-HSA-2028269 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | Mob Kinase Activator 1b proteinMob1 Homolog 1a proteinMob1a proteinMob1b proteinMps One Binder Kinase Activator-Like 1a proteinMOB1B proteinMOB4A proteinMOBKL1A protein |
Information sourced from Uniprot.org
