Human LRR1 protein (Recombinant) (N-His) (STJP008003)

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STJP008003
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human LRR1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: LRR1
Gene ID: 122769
Uniprot ID: LLR1_HUMAN
Immunogen Region: Lys135-Gly303
Immunogen: Homo sapiens (Human)
Function Substrate recognition subunit of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase. May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1.
Protein Name Leucine-Rich Repeat Protein 1
4-1bb-Mediated-Signaling Molecule
4-1bblrr
Lrr-Repeat Protein 1
Lrr-1
Peptidylprolyl Isomerase-Like 5
Database Links Reactome: R-HSA-8951664
Reactome: R-HSA-983168
Cellular Localisation Nucleus
Alternative Protein Names Leucine-Rich Repeat Protein 1 protein
4-1bb-Mediated-Signaling Molecule protein
4-1bblrr protein
Lrr-Repeat Protein 1 protein
Lrr-1 protein
Peptidylprolyl Isomerase-Like 5 protein
LRR1 protein
PPIL5 protein

Information sourced from Uniprot.org

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