Human LIMK2 protein (Recombinant) (N-His) (STJP007801)

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STJP007801
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human LIMK2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: LIMK2
Gene ID: 3985
Uniprot ID: LIMK2_HUMAN
Immunogen Region: Asp330-Pro638
Immunogen: Homo sapiens (Human)
Function Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP. Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro. Suppresses ciliogenesis via multiple pathways.phosphorylation of CFL1, suppression of directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1.
Protein Name Lim Domain Kinase 2
Limk-2
Database Links Reactome: R-HSA-3928662
Reactome: R-HSA-416572
Reactome: R-HSA-5627117
Cellular Localisation Cytoplasm
Cytoskeleton
Spindle
Microtubule Organizing Center
Centrosome
Isoform Limk2a: Cytoplasm
Nucleus
Isoform Limk2b: Cytoplasm
Perinuclear Region
Mainly Present In The Cytoplasm And Is Scarcely Translocated To The Nucleus
Alternative Protein Names Lim Domain Kinase 2 protein
Limk-2 protein
LIMK2 protein

Information sourced from Uniprot.org

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