| Post Translational Modifications | Proteolytically cleaved from endothelial cells surface into a soluble form by ADAM10 and ADAM17.the release of soluble JAM3 is increased by pro-inflammatory factors. S-palmitoylated by ZDHHC7. S-palmitoylation promotes expression at tight junctions. |
| Function | Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM2 to regulate different cellular processes. Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3. Plays a central role in leukocytes extravasation by facilitating transmigration through the endothelium. Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation. Also functions as a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). Plays a role in angiogenesis. Plays a role in the regulation of cell migration (Probable). During myogenesis, it is involved in myocyte fusion. Soluble form of JAM-C: Promotes chemotaxis of vascular endothelial cells and stimulates angiogenesis. |
| Protein Name | Junctional Adhesion Molecule CJam-CJam-2Junctional Adhesion Molecule 3Jam-3 Cleaved Into - Soluble Form Of Jam-CSjam-C |
| Database Links | Reactome: R-HSA-202733Reactome: R-HSA-216083 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionDesmosomeTight JunctionDetected In The Acrosome Region In Developing SpermatidsIn Epithelial CellsIt Is Expressed At Desmosomes But Not At Tight JunctionsLocalizes At The Cell Surface Of Endothelial CellsTreatment Of Endothelial Cells With Vascular Endothelial Growth Factor Stimulates Recruitment Of Jam3 To Cell-Cell ContactsSoluble Form Of Jam-C: Secreted |
| Alternative Protein Names | Junctional Adhesion Molecule C proteinJam-C proteinJam-2 proteinJunctional Adhesion Molecule 3 proteinJam-3 Cleaved Into - Soluble Form Of Jam-C proteinSjam-C proteinJAM3 proteinUNQ859 proteinPRO1868 protein |
Information sourced from Uniprot.org
