| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | ITPRIPL1 |
| Gene ID: | 150771 |
| Uniprot ID: | IPIL1_HUMAN |
| Immunogen Region: | His25-103Gly |
| Immunogen: | Recombinant Human ITPRIPL1/KIAA1754L/CD3L1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (His25-103Gly) of Human ITPRIPL1/KIAA1754L/CD3L1 (Accession #NP_001008949.1) fused with a His tag at the C |
| Immunogen Sequence: | SPLPITPVNA TCAIRHPCH G NLMNQIKSQL AQLNGSA NAL FISYYTAQGE PFPNN VDKLC APNMTDFPPF HAN GTEKTKL VELYRMVTYL G ASLTNITWD QKNLNPTAVS LQIKLNATTD VMRGLLSS VL CRLCNKYHVG HVDVPC VPDN SSKEAFQRKK LGCQ LLGTYK QVISVLAQAF |
| Tissue Specificity | Expressed in testis and tumoral cells. |
| Function | Functions as a ligand of CD3E, inhibiting TCR-CD3 complex signaling to regulate T cell activation. Induces stable CD3E-NCK1 binding, thereby preventing the CD3E-ZAP70 interaction and subsequently inhibiting the activation of the downstream ERK-NFkB signaling cascade and calcium influx. |
| Protein Name | Inositol 1 -4 -5-Trisphosphate Receptor-Interacting Protein-Like 1 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Inositol 1 -4 -5-Trisphosphate Receptor-Interacting Protein-Like 1 proteinITPRIPL1 proteinKIAA1754L protein |
Information sourced from Uniprot.org