Human ITPA protein (Recombinant) (N-His) (STJP006693)

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STJP006693
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human ITPA-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: ITPA
Gene ID: 3704
Uniprot ID: ITPA_HUMAN
Immunogen Region: Ala3-Arg180
Immunogen: Homo sapiens (Human)
Function Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Protein Name Inosine Triphosphate Pyrophosphatase
Itpase
Inosine Triphosphatase
Non-Canonical Purine Ntp Pyrophosphatase
Non-Standard Purine Ntp Pyrophosphatase
Nucleoside-Triphosphate Diphosphatase
Nucleoside-Triphosphate Pyrophosphatase
Ntpase
Putative Oncogene Protein Hlc14-06-P
Database Links Reactome: R-HSA-74259
Reactome: R-HSA-9755088
Cellular Localisation Cytoplasm
Alternative Protein Names Inosine Triphosphate Pyrophosphatase protein
Itpase protein
Inosine Triphosphatase protein
Non-Canonical Purine Ntp Pyrophosphatase protein
Non-Standard Purine Ntp Pyrophosphatase protein
Nucleoside-Triphosphate Diphosphatase protein
Nucleoside-Triphosphate Pyrophosphatase protein
Ntpase protein
Putative Oncogene Protein Hlc14-06-P protein
ITPA protein
C20orf37 protein
My049 protein
OK protein
SW-cl.9 protein

Information sourced from Uniprot.org

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