Human IREB2 protein (Recombinant) (N-His) (STJP004782)

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STJP004782
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human IREB2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: IREB2
Gene ID: 3658
Uniprot ID: IREB2_HUMAN
Immunogen Region: Pro39-Ser281
Immunogen: Homo sapiens (Human)
Function RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
Protein Name Iron-Responsive Element-Binding Protein 2
Ire-Bp 2
Iron Regulatory Protein 2
Irp2
Database Links Reactome: R-HSA-917937
Cellular Localisation Cytoplasm
Alternative Protein Names Iron-Responsive Element-Binding Protein 2 protein
Ire-Bp 2 protein
Iron Regulatory Protein 2 protein
Irp2 protein
IREB2 protein

Information sourced from Uniprot.org

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