| Tissue Specificity | Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin. |
| Function | Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response.similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. |
| Protein Name | Interleukin-36 Receptor Antagonist ProteinIl-36raFil1 DeltaIl-1-Related Protein 3Il-1rp3Interleukin-1 Hy1Il-1hy1Interleukin-1 DeltaIl-1 DeltaInterleukin-1 Family Member 5Il-1f5Interleukin-1 Receptor Antagonist Homolog 1Il-1ra Homolog 1Interleukin-1-Like Protein 1Il-1l1 |
| Database Links | Reactome: R-HSA-9014826 |
| Cellular Localisation | CytoplasmSecretedThe Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion |
| Alternative Protein Names | Interleukin-36 Receptor Antagonist Protein proteinIl-36ra proteinFil1 Delta proteinIl-1-Related Protein 3 proteinIl-1rp3 proteinInterleukin-1 Hy1 proteinIl-1hy1 proteinInterleukin-1 Delta proteinIl-1 Delta proteinInterleukin-1 Family Member 5 proteinIl-1f5 proteinInterleukin-1 Receptor Antagonist Homolog 1 proteinIl-1ra Homolog 1 proteinInterleukin-1-Like Protein 1 proteinIl-1l1 proteinIL36RN proteinFIL1D proteinIL1F5 proteinIL1HY1 proteinIL1L1 proteinIL1RP3 proteinUNQ1896 proteinPRO4342 protein |
Information sourced from Uniprot.org
