H) Western Blot of pDC-GEN2. 2 cell lysates for IL-28B/IFN Lambda 3 after 24 hours of HCV PAMP stimulation.

Human IL-28B protein (Recombinant) (STJP000651)

SKU:
STJP000651
£222.50 - £3,506.50
Free Shipping
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Host: CHO cells
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human IL-28B-protein was developed from cho cells. For use in research applications.
Conjugation: Unconjugated
Formulation: Lyophilised from 0.2 Mu m filtered PBS solution pH 7.4.
Dilution Range: Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers.
Storage Instruction: Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. NA
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA
Immunoreactivity: The activity was determined by a WISH cell viral resistance assay with a linear range of 4-20 ng/ml. NA
Gene Symbol: IFNL3
Gene ID: 282617
Uniprot ID: IFNL3_HUMAN
Immunogen Region: Mature chain
Immunogen: DNA sequence encoding mature chain of Human IL28B to a C-terminal polyHis tag was expressed in CHO cells. NA
Function Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
Protein Name Interferon Lambda-3
Ifn-Lambda-3
Cytokine Zcyto22
Interleukin-28b
Il-28b
Interleukin-28c
Il-28c
Database Links Reactome: R-HSA-8854691
Cellular Localisation Secreted
Alternative Protein Names Interferon Lambda-3 protein
Ifn-Lambda-3 protein
Cytokine Zcyto22 protein
Interleukin-28b protein
Il-28b protein
Interleukin-28c protein
Il-28c protein
IFNL3 protein
IL28B protein
IL28C protein
ZCYTO22 protein

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJP002601 Human IFN-lambda 3/IL-28B protein (Recombinant) (C-His) (STJP002601) HEK293 cells
STJP003109 Human IL-9 protein (Recombinant) (STJP003109) Human
STJP000485 Human IL-32 protein (Recombinant) (STJP000485) HEK293
STJP000704 Human IL-20RA protein (Recombinant) (STJP000704) HEK293
STJP001874 Human IL-16 protein (Recombinant) (STJP001874) HEK293
!