| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: | Measured by its binding ability in a functional ELISA. Immobilized Human IGHA1 at 5 Mu g/mL (100 Mu L/well) can bind Human CD89/FCAR with a linear range of 0.01-7.4 ng/mL. |
| Gene Symbol: | FCAR |
| Gene ID: | 2204 |
| Uniprot ID: | FCAR_HUMAN |
| Immunogen: | Recombinant Human IgA Fc receptor/CD89 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Gln22-Asn227) of human CD89/FCAR (Accession #NP_001991.1) fused with an Fc, 6×His tag at the C-terminus. |
| Immunogen Sequence: | QEGDFPMPFISAKSSPVIPL DGSVKIQCQAIREAYLTQLM IIKNSTYREIGRRLKFWNET DPEFVIDHMDANKAGRYQCQ YRIGHYRFRYSDTLELVVTG LYGKPFLSADRGLVLMPGEN ISLTCSSAHIPFDRFSLAKE GELSLPQHQSGEHPANFSLG PVDLNVSGIYRCYGWYNRSP YLWSFPSNALELVVTDSIHQ DYTTQN |
| Tissue Specificity | Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells. Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages.however only one isoform is expressed at alveolar macrophages surfaces. |
| Function | Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production. |
| Protein Name | Immunoglobulin Alpha Fc ReceptorIga Fc ReceptorCd Antigen Cd89 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Isoform A1: Cell MembraneSingle-Pass Type I Membrane Protein2: Cell Membrane3: Cell MembraneIsoform B: SecretedIsoform B-Delta-S2: Secreted |
| Alternative Protein Names | Immunoglobulin Alpha Fc Receptor proteinIga Fc Receptor proteinCd Antigen Cd89 proteinFCAR proteinCD89 protein |
Information sourced from Uniprot.org