• Human ICAM-1/CD54 protein (Recombinant) (C-His) (STJP001041)
  • Human ICAM-1/CD54 protein (Recombinant) (C-His) (STJP001041)
  • Human ICAM-1/CD54 protein (Recombinant) (C-His) (STJP001041)
  • Human ICAM-1/CD54 protein (Recombinant) (C-His) (STJP001041)
  • Human ICAM-1/CD54 protein (Recombinant) (C-His) (STJP001041)
  • Human ICAM-1/CD54 protein (Recombinant) (C-His) (STJP001041)

Human ICAM-1/CD54 protein (Recombinant) (C-His) (STJP001041)

SKU:
STJP001041

£72.50 - £324.50
Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human ICAM-1/CD54-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized APC Mouse Anti-Human CD54 at 1 Mu g/mL (25 Mu L/well) can bind Human CD54 with a linear range of 0.46-7.8 ng/mL.
Gene Symbol: ICAM1
Gene ID: 3383
Uniprot ID: ICAM1_HUMAN
Immunogen: Recombinant Human ICAM-1/CD54 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Gln28-Glu480) of human ICAM-1/CD54 (Accession #NP_000192.2) fused with a 6×His tag at the C-terminus.
Post Translational Modifications Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.
Function ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins. (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins. (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell.
Protein Name Intercellular Adhesion Molecule 1
Icam-1
Major Group Rhinovirus Receptor
Cd Antigen Cd54
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-216083
Reactome: R-HSA-6783783
Reactome: R-HSA-6785807
Reactome: R-HSA-877300
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Intercellular Adhesion Molecule 1 protein
Icam-1 protein
Major Group Rhinovirus Receptor protein
Cd Antigen Cd54 protein
ICAM1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance