Function | Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans. May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization. |
Protein Name | Serine Protease Htra3High-Temperature Requirement Factor A3Pregnancy-Related Serine Protease |
Cellular Localisation | SecretedSecretion Increased During Decidualization Of Endometrial Stromal Cells |
Alternative Protein Names | Serine Protease Htra3 proteinHigh-Temperature Requirement Factor A3 proteinPregnancy-Related Serine Protease proteinHTRA3 proteinPRSP protein |
Information sourced from Uniprot.org