Human HSP-27/HSPB1 (Heat Shock Protein Beta-1) Antibody Pair (STJAP00432)

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STJAP00432-50
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Host: Rabbit/Rabbit
Applications: ELISA
Reactivity: Human
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description : This HSP-27/HSPB1 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA.
Conjugation: Unconjugated/Biotin
Formulation: Capture Buffer: PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5.
Detection Buffer: PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5.
Purification: Capture Purification: Antigen Affinity.
Detection Purification: Antigen Affinity.
Concentration: 0.5 mg/mL
Storage Instruction: Store at-20°C for long term, and avoid freeze-thaw cycles.
Determination Method: Colormetric
Gene Symbol: HSPB1
Gene ID: 3315
Uniprot ID: HSPB1_HUMAN
Immunogen: Capture immunogen: Recombinant Human HSP-27/HSPB1 protien.
Detection Immunogen: Recombinant Human HSP-27/HSPB1 protien.
Sample Type: Serum, plasma and other biological fluids
Post Translational Modifications Phosphorylated upon exposure to protein kinase C activators and heat shock. Phosphorylation by MAPKAPK2 and MAPKAPK3 in response to stress dissociates HSPB1 from large small heat-shock protein (sHsps) oligomers and impairs its chaperone activity and ability to protect against oxidative stress effectively. Phosphorylation by MAPKAPK5 in response to PKA stimulation induces F-actin rearrangement.
Function Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins.
Protein Name Heat Shock Protein Beta-1
Hspb1
28 Kda Heat Shock Protein
Estrogen-Regulated 24 Kda Protein
Heat Shock 27 Kda Protein
Hsp 27
Heat Shock Protein Family B Member 1
Stress-Responsive Protein 27
Srp27
Database Links Reactome: R-HSA-4420097
Reactome: R-HSA-450408
Reactome: R-HSA-5687128
Reactome: R-HSA-9009391
Cellular Localisation Cytoplasm
Nucleus
Cytoskeleton
Spindle
Cytoplasmic In Interphase Cells
Colocalizes With Mitotic Spindles In Mitotic Cells
Translocates To The Nucleus During Heat Shock And Resides In Sub-Nuclear Structures Known As Sc35 Speckles Or Nuclear Splicing Speckles
Alternative Antibody Pair Names Heat Shock Protein Beta-1 antibody pair
Hspb1 antibody pair
28 Kda Heat Shock Protein antibody pair
Estrogen-Regulated 24 Kda Protein antibody pair
Heat Shock 27 Kda Protein antibody pair
Hsp 27 antibody pair
Heat Shock Protein Family B Member 1 antibody pair
Stress-Responsive Protein 27 antibody pair
Srp27 antibody pair
HSPB1 antibody pair
HSP27 antibody pair
HSP28 antibody pair

Information sourced from Uniprot.org

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