Human HSD11B2 protein (Recombinant) (N-His) (STJP006641)

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STJP006641
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human HSD11B2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: HSD11B2
Gene ID: 3291
Uniprot ID: DHI2_HUMAN
Immunogen Region: Gly106-Arg405
Immunogen: Homo sapiens (Human)
Function Catalyzes the conversion of biologically active 11beta-hydroxyglucocorticoids (11beta-hydroxysteroid) such as cortisol, to inactive 11-ketoglucocorticoids (11-oxosteroid) such as cortisone, in the presence of NAD(+). Functions as a dehydrogenase (oxidase), thereby decreasing the concentration of active glucocorticoids, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. Plays an important role in maintaining glucocorticoids balance during preimplantation and protects the fetus from excessive maternal corticosterone exposure. Catalyzes the oxidation of 11beta-hydroxytestosterone (11beta,17beta-dihydroxyandrost-4-ene-3-one) to 11-ketotestosterone (17beta-hydroxyandrost-4-ene-3,11-dione), a major bioactive androgen. Catalyzes the conversion of 11beta-hydroxyandrostenedione (11beta-hydroxyandrost-4-ene-3,17-dione) to 11-ketoandrostenedione (androst-4-ene-3,11,17-trione), which can be further metabolized to 11-ketotestosterone. Converts 7-beta-25-dihydroxycholesterol to 7-oxo-25-hydroxycholesterol in vitro. 7-beta-25-dihydroxycholesterol (not 7-oxo-25-hydroxycholesterol) acts as a ligand for the G-protein-coupled receptor (GPCR) Epstein-Barr virus-induced gene 2 (EBI2) and may thereby regulate immune cell migration. May protect ovulating oocytes and fertilizing spermatozoa from the adverse effects of cortisol.
Protein Name 11-Beta-Hydroxysteroid Dehydrogenase Type 2
11-Dh2
11-Beta-Hsd2
11-Beta-Hydroxysteroid Dehydrogenase Type Ii
11-Hsd Type Ii
11-Beta-Hsd Type Ii
Corticosteroid 11-Beta-Dehydrogenase Isozyme 2
Nad-Dependent 11-Beta-Hydroxysteroid Dehydrogenase
Short Chain Dehydrogenase/Reductase Family 9c Member 3
Database Links Reactome: R-HSA-194002
Reactome: R-HSA-9757110
Cellular Localisation Microsome
Endoplasmic Reticulum
Alternative Protein Names 11-Beta-Hydroxysteroid Dehydrogenase Type 2 protein
11-Dh2 protein
11-Beta-Hsd2 protein
11-Beta-Hydroxysteroid Dehydrogenase Type Ii protein
11-Hsd Type Ii protein
11-Beta-Hsd Type Ii protein
Corticosteroid 11-Beta-Dehydrogenase Isozyme 2 protein
Nad-Dependent 11-Beta-Hydroxysteroid Dehydrogenase protein
Short Chain Dehydrogenase/Reductase Family 9c Member 3 protein
HSD11B2 protein
HSD11K protein
SDR9C3 protein

Information sourced from Uniprot.org

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